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The research team PRODICET focuses its study on the mechanisms involved in the initiation, progression, and dissemination of primary and secondary brain tumors represented below. Within our laboratory, two pathologies relating to tumor cell development and dissemination within the brain are studied in parallel: (i) gliomas, locally invasive primary brain tumors and ii) secondary colorectal and breast cerebral tumors. The mechanisms that lead tumor cells to spread preferentially to the brain are still poorly understood. Our main objective is to identify predictive or prognostic markers of tumor cell cerebral spreading and to consolidate the basis to develop therapeutic approaches focused on the targeted inhibition of events relating to tumor growth and/or dissemination in the brain. PRODICET’s current research project is divided into three interdependent work packages, each described on this website.
Our previous studies identified the factors belonging to the HIPPO signaling pathway, particularly YAP1, as independent prognostic factors for low-grade gliomas. Since then, we try to understand this pathway’s role in the various cellular and molecular mechanisms allowing the development of primary and secondary brain tumors.
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Our research, confirmed by other international research teams, underlined the involvement of the TAM tyrosine kinase receptors family (including TYRO3, AXL et MERTK) and one of their ligand, the Protein S, in different cellular processes linked to the development of metastases. Our team PRODICET continues its study of these proteins in these mechanisms, particularly in brain metastases cancer stem cells from colorectal cancer.
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Our research, supported by numerous other findings, pointed out the significance of tumor-derived exosomes’ role in the regulation of the tumor microenvironment and its effects on tumor growth. Our study is still in progress on patients’ metastasis-derived breast cancer stem cells.
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